Ethyl Acetate → (2-methyl-1H-1,3-benzodiazol-5-yl)methanamine
Reaction equation
O[CH2:2][C:3]1[CH:12]=[CH:11][C:6]2[N:7]=[C:8]([CH3:10])[NH:9][C:5]=2[CH:4]=1.CCOC(C)=O.[NH4+:19].[OH-]>CO>[NH2:19][CH2:2][C:3]1[CH:12]=[CH:11][C:6]2[N:7]=[C:8]([CH3:10])[NH:9][C:5]=2[CH:4]=1Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
The title compound was prepared from 5-(hydroxymethyl)-2-methylbenzimidazole: Rf (8:1:1 EtOAc:MeOH:NH4OH)=0.15. 1H NMR (300 MHz, CD3OD): δ7.45 (m, 2H), 7.20 (d, J=8.1 Hz, 1H), 3.90 (s, 2H), 2.56 (s, 3H).
Sources & evidence
- ORD record
- ord-c1db111fffca40ec990b36119c2c95cc
- Source dataset
- uspto-grants-2003_08
- Patent number
- US06610701B2
Reaction notes
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