Sulfuric Acid → Quinacridone

HRID 399183

Reaction equation

HRID 399183 reaction equation
[CH2:1]1[C:6]2[NH:7][C:8]3[C:13]([C:14](=[O:15])[C:5]=2[CH2:4][C:3]2[NH:16][C:17]4[C:22]([C:23](=[O:24])[C:2]1=2)=[CH:21][CH:20]=[CH:19][CH:18]=4)=[CH:12][CH:11]=[CH:10][CH:9]=3.[OH-].[Na+].S(=O)(=O)(O)O.[N+](C1C=C(S([O-])(=O)=O)C=CC=1)([O-])=O.[Na+]>CO>[CH:20]1[CH:21]=[C:22]2[C:23]([C:2]3[C:3]([NH:16][C:17]2=[CH:18][CH:19]=1)=[CH:4][C:5]1[C:14]([C:13]2[C:8]([NH:7][C:6]=1[CH:1]=3)=[CH:9][CH:10]=[CH:11][CH:12]=2)=[O:15])=[O:24]

Participants

6

Reactant 4

HCID 1118Sulfuric AcidHCID 14798Sodium HydroxideHCID 31389Sodium 3-nitrobenzenesulfonateHCID 79973Quino(2,3-b)acridine-7,14-dione, 5,6,12,13-tetrahydro-

Product 1

HCID 13976Quinacridone

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

10 Parts of the 6,13-dihydroquinacridone obtained in Example 9 and 80 parts of methanol were charged into a 200-ml flask having a refluxer, and stirred. 12 Parts of a 50% NaOH aqueous solution was added, and the mixture was stirred at 40° C. for 30 minutes to form a salt. 40 Parts of 10% sulfuric acid was added dropwise to hydrolyze the salt, and the reaction mixture was refluxed under for 1 hour. 10 Parts of sodium m-nitrobenzenesulfonate was added, and the mixture was refluxed for 4 hours to give 9.76 parts (98.2% of the theoretical yield) of an unsubstituted quinacridone having an excellent particle diameter as a pigment.

Workup

  1. stirringthe mixture was stirred at 40° C. for 30 minutes
  2. customto form a salt
  3. temperaturethe reaction mixture was refluxed under for 1 hour
  4. temperaturethe mixture was refluxed for 4 hours
  5. customto give 9.76 parts (98.2% of the

Sources & evidence

ORD record
ord-d6633d6c04b641ee94b6f2415663560f
Source dataset
uspto-grants-1998_10
Patent number
US05817817

Linked notes

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