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Hydrochloric Acid → 3-(5-(2-((4'-Chloro-[1,1'-biphenyl]-4-yl)carbamoyl)-5-methylphenyl)picolinamido)propanoic acid

HRID 405222
Notes
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Reaction equation

HRID 405222 reaction equation
[OH-].[Na+].C1COCC1.[Cl:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:20]=[CH:19][C:18]([NH:21][C:22]([C:24]3[CH:29]=[CH:28][C:27]([CH3:30])=[CH:26][C:25]=3[C:31]3[CH:32]=[CH:33][C:34]([C:37]([NH:39][CH2:40][CH2:41][C:42]([O:44]CC)=[O:43])=[O:38])=[N:35][CH:36]=3)=[O:23])=[CH:17][CH:16]=2)=[CH:11][CH:10]=1.Cl>CO>[Cl:8][C:9]1[CH:10]=[CH:11][C:12]([C:15]2[CH:20]=[CH:19][C:18]([NH:21][C:22]([C:24]3[CH:29]=[CH:28][C:27]([CH3:30])=[CH:26][C:25]=3[C:31]3[CH:32]=[CH:33][C:34]([C:37]([NH:39][CH2:40][CH2:41][C:42]([OH:44])=[O:43])=[O:38])=[N:35][CH:36]=3)=[O:23])=[CH:17][CH:16]=2)=[CH:13][CH:14]=1
ParticipantsConditionsProcedureWorkupSources & evidenceReaction notes

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 8028TetrahydrofuranHCID 14798Sodium HydroxideHCID 71060074Ethyl 3-(5-(2-((4'-chloro-[1,1'-biphenyl]-4-yl)carbamoyl)-5-methylphenyl)picolinamido)propanoate

Product 1

HCID 710599823-(5-(2-((4'-Chloro-[1,1'-biphenyl]-4-yl)carbamoyl)-5-methylphenyl)picolinamido)propanoic acid

Reagents, catalysts & solvents

1
HCID 887MethanolSolvent

Conditions

Temperature
55 °C

Procedure

A 1M aqueous solution of NaOH (2.0 mL, 2.0 mmol) was added to a THF (1 mL) and MeOH (5 mL) solution of ethyl 3-(5-(2-((4′-chloro-[1,1′-biphenyl]-4-yl)carbamoyl)-5-methylphenyl)picolinamido)propanoate (50 mg, 0.09 mmol) and the resulting mixture was heated to 55° C. After 10 min the resulting mixture was neutralized with 2M aqueous HCl, concentrated and extracted with EtOAc. The combined extracts were concentrated and purified via column chromatography to yield the title compound.

Workup

  1. concentrationconcentrated
  2. extractionextracted with EtOAc
  3. concentrationThe combined extracts were concentrated
  4. custompurified via column chromatography

Sources & evidence

ORD record
ord-136f895b3c5c46edb300f2cca00f7cfe
Source dataset
uspto-grants-2014_06
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US08748624B2

Reaction notes

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On this pageParticipantsConditionsProcedureWorkupSources & evidenceReaction notes