Oxalyl chloride → HCID 59625951, compound
Reaction equation
[Cl:1][C:2]1[CH:17]=[CH:16][C:5]2[S:6][C:7]([C:13](O)=[O:14])=[C:8]([C:9]([F:12])([F:11])[F:10])[C:4]=2[CH:3]=1.C(Cl)(C([Cl:22])=O)=O>C(Cl)Cl.CN(C=O)C>[Cl:1][C:2]1[CH:17]=[CH:16][C:5]2[S:6][C:7]([C:13]([Cl:22])=[O:14])=[C:8]([C:9]([F:12])([F:11])[F:10])[C:4]=2[CH:3]=1Participants
5
Reactant 2
Product 1
Reagents, catalysts & solvents 2
Procedure
To compound 18f in CH2Cl2 (5 mL) at room temperature was added (COCl)2, followed by 2 drops of DMF. The reaction mixture was stirred at room temperature for 18 h. The reaction mixture was then concentrated to give compound 18g.
Workup
- concentrationThe reaction mixture was then concentrated
Sources & evidence
- ORD record
- ord-33489a48cd394b749c728bb541670be1
- Source dataset
- uspto-grants-2014_06
- Patent number
- US08759533B2
Reaction notes
Loading…