Sodium hydride → 2-(2-Chloroethyl)-5-phenyl-1,2,5-thiadiazolidine-1,1-dioxide
Reaction equation
[Cl:1][CH2:2][CH2:3][N:4]([CH2:15][CH2:16]Cl)[S:5]([NH:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)(=[O:7])=[O:6].[H-].[Na+]>CN(C=O)C>[Cl:1][CH2:2][CH2:3][N:4]1[CH2:15][CH2:16][N:8]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[S:5]1(=[O:7])=[O:6]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
Using a slow dropper, a solution of 12.6 g of the product obtained in Step 2 above in 25 ml of DMF is introduced onto a suspension of 1.4 g of NaH in 175 ml of DMF and stirring is carried out for 12 hours. The reaction mixture is then poured onto ice in order to bring about crystallisation of the expected product.
Workup
- additionThe reaction mixture is then poured onto ice in order
- customto bring about crystallisation of the expected product
Sources & evidence
- ORD record
- ord-7fc9ec499689454980b9669c39b87220
- Source dataset
- uspto-grants-2003_05
- Patent number
- US06566364B2
Reaction notes
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