Benzoyl chloride → HCID 15615417, compound

HRID 413324

Reaction equation

HRID 413324 reaction equation
[C:1](Cl)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Br.[Br:11][CH:12]1[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1.C(N(CC)CC)C>C1COCC1>[C:1]([N:15]1[CH2:16][CH2:17][CH:12]([Br:11])[CH2:13][CH2:14]1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 7412Benzoyl chlorideHCID 8471TriethylamineHCID 27346764-Bromopiperidine Hydrobromide

Product 1

HCID 15615417HCID 15615417, compoundYield 102.9%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Benzoyl chloride (1.41 g) was added to a solution of 4-bromopiperidine hydrobromide (2.45 g) in THF (30 ml) at 0° C., followed by triethylamine (2.2 g, 2.2 eq). The solution was stirred at room temperature for 1 h, and evaporated and. The residue was dissolved in dichloromethane (100 ml), washed with water, 1M HCl and saturated sodium bicarbonate, dried and evaporated to give the title compound as colourless oil (2.76 g, 100%).

Workup

  1. customevaporated
  2. dissolutionThe residue was dissolved in dichloromethane (100 ml)
  3. washwashed with water, 1M HCl and saturated sodium bicarbonate
  4. customdried
  5. customevaporated

Sources & evidence

ORD record
ord-566845940e95481a8df6a102b049709e
Source dataset
uspto-grants-2003_05
Patent number
US06566384B1

Linked notes

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