Hydrogen Bromide → HCID 68820841, compound

HRID 41499

Reaction equation

HRID 41499 reaction equation
CS(C)=O.[BrH:5].[CH3:6][C:7]1[CH:15]=[C:14]([C:16]([NH:18][C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([C:25]3[C:34]4[C:29](=[CH:30][C:31]([O:37][CH3:38])=[C:32]([O:35][CH3:36])[CH:33]=4)[N:28]=[C:27]([NH:39][CH3:40])[N:26]=3)[CH:20]=2)=[O:17])[CH:13]=[CH:12][C:8]=1[C:9]([OH:11])=[O:10]>CC(O)C>[BrH:5].[CH3:6][C:7]1[CH:15]=[C:14]([C:16]([NH:18][C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([C:25]3[C:34]4[C:29](=[CH:30][C:31]([O:37][CH3:38])=[C:32]([O:35][CH3:36])[CH:33]=4)[N:28]=[C:27]([NH:39][CH3:40])[N:26]=3)[CH:20]=2)=[O:17])[CH:13]=[CH:12][C:8]=1[C:9]([OH:11])=[O:10]

Participants

5

Reactant 3

HCID 260Hydrogen BromideHCID 679Dimethyl SulfoxideHCID 66646296methyl N-[3-(6,7-dimethoxy-2-methylaminoquinazolin-4-yl)phenyl]terephthalamic acid

Product 1

HCID 68820841HCID 68820841, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

Dimethyl sulfoxide (1 mL) and hydrobromic acid (40 μL) were added to methyl N-[3-(6,7-dimethoxy-2-methylaminoquinazolin-4-yl)phenyl]terephthalamic acid (100.90 mg). 2-Propanol (5 mL) was added to the mixture while heating the mixture, and the mixture was cooled to room temperature to be solidified. The solid was collected by filtration to yield the titled compound (108.92 mg).

Workup

  1. temperaturewhile heating the mixture
  2. filtrationThe solid was collected by filtration

Sources & evidence

ORD record
ord-c3aa049b7aa9465693f6054ed6d6261f
Source dataset
uspto-grants-2013_09
Patent number
US08530654B2

Linked notes

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