4-Hydroxybenzaldehyde → 4-((2-Fluorophenyl)methoxy)benzaldehyde

Reaction equation

[OH:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[CH:4][CH:3]=1.[F:10][C:11]1[CH:18]=[CH:17][CH:16]=[CH:15][C:12]=1[CH2:13]Cl>>[F:10][C:11]1[CH:18]=[CH:17][CH:16]=[CH:15][C:12]=1[CH2:13][O:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 1264-Hydroxybenzaldehyde

HCID 9580Benzene, 1-(chloromethyl)-2-fluoro-

Product 1

HCID 7027174-((2-Fluorophenyl)methoxy)benzaldehyde

Procedure

4-(2-Fluorobenzyloxy)benzaldehyde is prepared by alkylation of 4-hydroxybenzaldehyde (0.39 g) with 2-fluorobenzyl chloride by following the same procedure of Example 1, but using three different phase transfer catalysts.

Sources & evidence

ORD record: ord-98f7225d9ac847d8aeb49aa56a0d9395
Source dataset: uspto-grants-2013_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08530701B2

Reaction notes

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