Methylamine → HCID 178482273, compound

HRID 41776

Reaction equation

HRID 41776 reaction equation
[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([N:10]3[CH:14]([C:15]4[CH:20]=[CH:19][C:18]([N:21]5[CH2:26][CH2:25][O:24][CH2:23][CH2:22]5)=[CH:17][CH:16]=4)[C:13](O)=[CH:12][C:11]3=[O:28])=[CH:9][C:4]=2[N:3]=[CH:2]1.[CH3:29][NH2:30]>C1COCC1.C1(C)C=CC=CC=1.CN(C=O)C>[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([N:10]3[CH:14]([C:15]4[CH:16]=[CH:17][C:18]([N:21]5[CH2:22][CH2:23][O:24][CH2:25][CH2:26]5)=[CH:19][CH:20]=4)[C:13]([NH:30][CH3:29])=[CH:12][C:11]3=[O:28])=[CH:9][C:4]=2[N:3]=[CH:2]1

Participants

5

Reactant 2

HCID 6329MethylamineHCID 178516575HCID 178516575, compound

Product 1

HCID 178482273HCID 178482273, compound

Reagents, catalysts & solvents 2

HCID 8028TetrahydrofuranSolventHCID 21735183Dimethylformamide tolueneSolvent

Procedure

The compound was synthesized starting from 1-(1H-benzo[d]imidazol-5-yl)-4-hydroxy-5-(4-morpholinophenyl)-1H-pyrrol-2(5H)-one (0.50 g, 1.32 mmol) and saturated methylamine solution in THF (1 ml) in toluene/DMF (2:1; 5 ml) according to method 8b described above.

Workup

  1. customThe compound was synthesized

Sources & evidence

ORD record
ord-0e2372ce3a6844acb3519e6603f4abeb
Source dataset
uspto-grants-2013_09
Patent number
US08530670B2

Linked notes

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