Acetic Anhydride → N-(4-amino-2-chloropyridin-3-yl)acetamide

HRID 420879

Reaction equation

HRID 420879 reaction equation
[NH2:1][C:2]1[C:3]([Cl:9])=[N:4][CH:5]=[CH:6][C:7]=1[NH2:8].[C:10](OC(=O)C)(=[O:12])[CH3:11]>C1COCC1>[NH2:8][C:7]1[CH:6]=[CH:5][N:4]=[C:3]([Cl:9])[C:2]=1[NH:1][C:10](=[O:12])[CH3:11]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 2857362-Chloropyridine-3,4-diamine

Product 1

HCID 45119288N-(4-amino-2-chloropyridin-3-yl)acetamide

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

1.1 A solution of 10.0 g of 3,4-diamino-2-chloropyridine and 6.62 ml of acetic anhydride in 100 ml of THF is stirred at room temperature for 16 hours. The product is separated off and dried, giving 7.3 g of N-(4-amino-2-chloropyridin-3-yl)acetamide (“1”).

Workup

  1. customThe product is separated off
  2. customdried

Sources & evidence

ORD record
ord-855e4986caed43f8929211014d5c50e5
Source dataset
uspto-grants-2012_01
Patent number
US08097727B2

Linked notes

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