Piperidine → 1-Piperidinesulfonamide

HRID 424687

Reaction equation

HRID 424687 reaction equation
[NH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[S:7](N)([NH2:10])(=[O:9])=[O:8]>O1CCOCC1>[N:1]1([S:7]([NH2:10])(=[O:9])=[O:8])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 8082PiperidineHCID 82267Sulfamide

Product 1

HCID 2767411-Piperidinesulfonamide

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Piperidine (3.0 g) and sulfamide (5.93 g) in 1,4-dioxane (100 ml) were heated at reflux for 24 h. The solvent was evaporated under reduced pressure and the resulting solid suspended in CHCl3. The suspension was filtered and the filtrate concentrated in vacuo to afford the subtitle compound as a white solid. Yield: 3.85 g.

Workup

  1. temperatureat reflux for 24 h
  2. customThe solvent was evaporated under reduced pressure
  3. filtrationThe suspension was filtered
  4. concentrationthe filtrate concentrated in vacuo

Sources & evidence

ORD record
ord-ee0d5e1762a847a1929db3d27db38938
Source dataset
uspto-grants-2012_01
Patent number
US08106063B2

Linked notes

Loading…