Cyclopentylamine → 4-Chloro-2-(cyclopentylamino)benzonitrile

HRID 425959

Reaction equation

HRID 425959 reaction equation
[CH:1]1([NH2:6])[CH2:5][CH2:4][CH2:3][CH2:2]1.C(=O)([O-])[O-].[K+].[K+].[Cl:13][C:14]1[CH:21]=[CH:20][C:17]([C:18]#[N:19])=[C:16](F)[CH:15]=1>CN(C=O)C>[Cl:13][C:14]1[CH:21]=[CH:20][C:17]([C:18]#[N:19])=[C:16]([NH:6][CH:1]2[CH2:5][CH2:4][CH2:3][CH2:2]2)[CH:15]=1

Participants

5

Reactant 3

HCID 2906CyclopentylamineHCID 11430Potassium CarbonateHCID 936554-Chloro-2-fluorobenzonitrile

Product 1

HCID 436815104-Chloro-2-(cyclopentylamino)benzonitrile

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
100 °C

Procedure

Cyclopentylamine and potassium carbonate were added to a DMF solution of 4-chloro-2-fluorobenzonitrile, followed by stirring at 100° C. for 12 hours. By post-treating the reaction liquid, 4-chloro-2-(cyclopentylamino)benzonitrile was obtained.

Workup

  1. additionBy post-treating
  2. customthe reaction liquid

Sources & evidence

ORD record
ord-5f11b7f2f9c34c1c822d468a41e92ad5
Source dataset
uspto-grants-2012_01
Patent number
US08106190B2

Linked notes

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