Water → 5,8-Difluoro-1,4-benzodioxane

HRID 426746

Reaction equation

HRID 426746 reaction equation
F[C:2]1[C:11]([F:12])=[CH:10][CH:9]=[C:8]([F:13])[C:3]=1[O:4][CH2:5][CH2:6][OH:7].C(=O)([O-])[O-].[K+].[K+].O>CN(C)C=O>[F:12][C:11]1[C:2]2[O:7][CH2:6][CH2:5][O:4][C:3]=2[C:8]([F:13])=[CH:9][CH:10]=1

Participants

5

Reactant 3

HCID 962WaterHCID 11430Potassium CarbonateHCID 27779442-(2,3,6-Trifluorophenoxy)ethanol

Product 1

HCID 44642425,8-Difluoro-1,4-benzodioxane

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

2-(2,3,6-Trifluorophenoxy) ethanol (48.8 g, 0.254 mole) and 24 g of anhydrous potassium carbonate in 800 ml of dimethylformamide was refluxed for 20 hours and then poured into water. This was extracted with ether, washed with water, and dried to give 5,8-difluoro-1,4-benzodioxane.

Workup

  1. extractionThis was extracted with ether
  2. washwashed with water
  3. customdried

Sources & evidence

ORD record
ord-f8ca3c9a2c7248d7b8e319529edd37db
Source dataset
uspto-grants-1979_10
Patent number
US04171359

Linked notes

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