Tetrahydrofuran → Methyl-dithiane triflate

HRID 43296

Reaction equation

HRID 43296 reaction equation
[S:1]1[CH2:6]CSCC1.C[O:8][S:9]([C:12]([F:15])([F:14])[F:13])(=[O:11])=[O:10].O1[CH2:20][CH2:19][CH2:18][CH2:17]1>>[OH:11][S:9]([C:12]([F:15])([F:14])[F:13])(=[O:10])=[O:8].[CH3:17][CH:18]1[CH2:19][CH2:20][CH2:6][S:1][S:9]1

Participants

4

Reactant 3

HCID 8028TetrahydrofuranHCID 9526Methyl triflateHCID 104521,4-Dithiane

Product 1

HCID 87663609Methyl-dithiane triflate

Procedure

2 mmol of 1,4-dithiane was dissolved in 8 ml of tetrahydrofuran at 0° C., and about 2 mmol of methyltrifluoromethane sulfonate was slowly dripped to the mixture. After 20 minutes a white solid product was obtained in a salt form. The solid product was filtered and dried for 1 hour in an oven at 50° C. to obtain the following product:

Workup

  1. customAfter 20 minutes a white solid product was obtained in a salt form
  2. filtrationThe solid product was filtered
  3. customdried for 1 hour in an oven at 50° C.
  4. customto obtain the following product

Sources & evidence

ORD record
ord-41398a64833a4e6c9154b9c531f8a831
Source dataset
uspto-grants-2013_09
Patent number
US08536347B2

Linked notes

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