Tetrahydrofuran → Methyl-dithiane triflate
Reaction equation
[S:1]1[CH2:6]CSCC1.C[O:8][S:9]([C:12]([F:15])([F:14])[F:13])(=[O:11])=[O:10].O1[CH2:20][CH2:19][CH2:18][CH2:17]1>>[OH:11][S:9]([C:12]([F:15])([F:14])[F:13])(=[O:10])=[O:8].[CH3:17][CH:18]1[CH2:19][CH2:20][CH2:6][S:1][S:9]1Participants
4
Procedure
2 mmol of 1,4-dithiane was dissolved in 8 ml of tetrahydrofuran at 0° C., and about 2 mmol of methyltrifluoromethane sulfonate was slowly dripped to the mixture. After 20 minutes a white solid product was obtained in a salt form. The solid product was filtered and dried for 1 hour in an oven at 50° C. to obtain the following product:
Workup
- customAfter 20 minutes a white solid product was obtained in a salt form
- filtrationThe solid product was filtered
- customdried for 1 hour in an oven at 50° C.
- customto obtain the following product
Sources & evidence
- ORD record
- ord-41398a64833a4e6c9154b9c531f8a831
- Source dataset
- uspto-grants-2013_09
- Patent number
- US08536347B2
Reaction notes
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