Gamma-Butyrolactone → 1-(3-Hydroxypropyl)pyrrolidin-2-one

HRID 434478

Reaction equation

[NH2:1][CH2:2][CH2:3][CH2:4][OH:5].[C:6]1(=O)[O:10][CH2:9][CH2:8][CH2:7]1>>[OH:5][CH2:4][CH2:3][CH2:2][N:1]1[CH2:6][CH2:7][CH2:8][C:9]1=[O:10]

Participants

Reactant 2

HCID 7302Gamma-Butyrolactone

HCID 90863-Amino-1-propanol

Product 1

HCID 5667441-(3-Hydroxypropyl)pyrrolidin-2-oneYield 78.6%

Procedure

3-aminopropanol reacted in similar manner to Example 2 with butyrolactone furnished a 78.6% yield of N-(3-hydroxypropyl)-2-pyrrolidinone, b.p. 160° C./3 torr.

Sources & evidence

ORD record: ord-3e1a5ff4ce164c42a7adb84af9fec025
Source dataset: uspto-grants-1983_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04397750

Linked notes

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