Lysine hydrochloride, D- → Lysine hydrochloride, DL-

HRID 435466

Reaction equation

HRID 435466 reaction equation
[ClH:1].[NH2:2][C@@H:3]([C:9]([OH:11])=[O:10])[CH2:4][CH2:5][CH2:6][CH2:7][NH2:8].C(O)C.CC(C)=O>C(O)(=O)C.C(=O)C1C(=CC=CC=1)O>[ClH:1].[NH2:2][CH:3]([C:9]([OH:11])=[O:10])[CH2:4][CH2:5][CH2:6][CH2:7][NH2:8]

Participants

5

Reactant 2

HCID 81691Lysine hydrochloride, D-HCID 21889777Acetone ethanol

Product 1

HCID 12047Lysine hydrochloride, DL-Yield 93.3%

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 6998SalicylaldehydeSolvent

Conditions

Temperature
100 °C

Procedure

6 g of D-lysine monohydrochloride were dissolved in 180 ml of an aqueous 95% acetic acid solution, and 0.34 ml of salicylaldehyde was added thereto. The mixture was stirred at 100° C. for 3 hours. After the reaction, the mixture was condensed. 30 ml of 50% ethanol-acetone were added to the residue, and the crystalline precipitates were collected by filtration. 5.6 g of DL-lysine monohydrochloride were thereby obtained.

Workup

  1. additionwas added
  2. customAfter the reaction
  3. customcondensed
  4. customthe crystalline precipitates
  5. filtrationwere collected by filtration

Sources & evidence

ORD record
ord-4f89e8343cde4b438e067a55fe787f2c
Source dataset
uspto-grants-1983_08
Patent number
US04401820

Linked notes

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