C1(C)C=CC=CC=1.[OH-].[Na+].[Cl:10][C:11]1[CH:30]=[CH:29][C:14]([CH:15]=[C:16]2[CH2:20][CH2:19][C:18]([CH:25]([CH3:27])[CH3:26])(C(OC)=O)[C:17]2=[O:28])=[CH:13][CH:12]=1.Cl>O.C(O)(C)C>[Cl:10][C:11]1[CH:12]=[CH:13][C:14]([CH:15]=[C:16]2[CH2:20][CH2:19][CH:18]([CH:25]([CH3:27])[CH3:26])[C:17]2=[O:28])=[CH:29][CH:30]=1
To a mixed solution of 150 ml of toluene, 50 ml of isopropanol, and 100 ml of water were added 58.6 g of sodium hydroxide and 50 g of methyl 3-(4-chlorobenzylidene)-1-isopropyl-2-oxocylopentanecarboxylate (prepared in Example 2). The mixture was stirred for 4 hours at 70°-80° C. The reaction mixture was poured into 2000 ml of 10% aqueous solution of hydrochloric acid and extracted with 300 ml of ethyl acetate. The organic layer was washed with water and dried, followed by evaporation of the solvent to obtain the target compound.
Loading…
