Thiazolidinedione → 5-(4-Chlorobenzylidene)-2,4-thiazolidinedione
Reaction equation
[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=O)=[CH:4][CH:3]=1.[S:10]1[CH2:14][C:13](=[O:15])[NH:12][C:11]1=[O:16].N1CCCCC1>C(O)C>[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[C:14]2[S:10][C:11](=[O:16])[NH:12][C:13]2=[O:15])=[CH:4][CH:3]=1Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
A solution of 4-chloro-benzaldehyde (3 mmoles), thiazolidine-2,4-dione (3 mmoles) and piperidine (3 mmoles) in ethanol is heated at reflux overnight.
Workup
- temperatureat reflux overnight
Sources & evidence
- ORD record
- ord-b1b1f6883b3a46ce97f73066add5282a
- Source dataset
- uspto-grants-2013_09
- Patent number
- US08541412B2
Reaction notes
Loading…