Thiazolidinedione → 5-(4-Chlorobenzylidene)-2,4-thiazolidinedione

HRID 44269

Reaction equation

HRID 44269 reaction equation
[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=O)=[CH:4][CH:3]=1.[S:10]1[CH2:14][C:13](=[O:15])[NH:12][C:11]1=[O:16].N1CCCCC1>C(O)C>[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[C:14]2[S:10][C:11](=[O:16])[NH:12][C:13]2=[O:15])=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 5437ThiazolidinedioneHCID 77264-ChlorobenzaldehydeHCID 8082Piperidine

Product 1

HCID 2330705-(4-Chlorobenzylidene)-2,4-thiazolidinedione

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 4-chloro-benzaldehyde (3 mmoles), thiazolidine-2,4-dione (3 mmoles) and piperidine (3 mmoles) in ethanol is heated at reflux overnight.

Workup

  1. temperatureat reflux overnight

Sources & evidence

ORD record
ord-b1b1f6883b3a46ce97f73066add5282a
Source dataset
uspto-grants-2013_09
Patent number
US08541412B2

Linked notes

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