Hydrochloric Acid → 3-[(1-Methylpiperidin-4-yl)oxy]aniline

HRID 44642

Reaction equation

HRID 44642 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][CH:5]([O:8][C:9]2[CH:10]=[C:11]([NH:15]C(=O)C)[CH:12]=[CH:13][CH:14]=2)[CH2:4][CH2:3]1.Cl>C(O)C>[CH3:1][N:2]1[CH2:3][CH2:4][CH:5]([O:8][C:9]2[CH:10]=[C:11]([NH2:15])[CH:12]=[CH:13][CH:14]=2)[CH2:6][CH2:7]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 57444159N-[3-(1-Methyl-piperidin-4-yloxy)-phenyl]-acetamide

Product 1

HCID 392026543-[(1-Methylpiperidin-4-yl)oxy]aniline

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of N-[3-(1-Methyl-piperidin-4-yloxy)-phenyl]-acetamide (2.604 g) in absolute ethanol (40 mL) was treated with 37% hydrochloric acid and the solution was heated to reflux for 3 hours.

Workup

  1. temperaturethe solution was heated
  2. temperatureto reflux for 3 hours

Sources & evidence

ORD record
ord-6031bf9140c847b7b1fab5f57e68279e
Source dataset
uspto-grants-2013_09
Patent number
US08541429B2

Linked notes

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