Triethylamine → 1246210-02-5
Reaction equation
[F:1][C:2]1([F:11])[CH2:7][CH2:6][CH:5](C(O)=O)[CH2:4][CH2:3]1.C1C=CC(OP([O:24][C:25]2C=CC=CC=2)(N=[N+]=[N-])=O)=CC=1.C([N:33](CC)CC)C>C1(C)C=CC=CC=1>[F:11][C:2]1([F:1])[CH2:3][CH2:4][CH:5]([N:33]=[C:25]=[O:24])[CH2:6][CH2:7]1Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
A mixture of 4,4-difluorocyclohexanecarboxylic acid (0.20 g, 1.2 mmol) (Matrix Scientific, Cat. #018320), diphenylphosphonic azide (0.67 g, 2.4 mmol) (Aldrich, Cat. #178756) and triethylamine (0.51 mL, 3.6 mmol) in toluene (10 mL) was refluxed overnight. The volatiles were removed under reduced pressure to afford the product which was directly used for next step reaction without further purification.
Workup
- temperaturewas refluxed overnight
- customThe volatiles were removed under reduced pressure
- customto afford the product which
- customwas directly used for next step reaction without further purification
Sources & evidence
- ORD record
- ord-2cc29ac6cfff4aecab4930936f6dced6
- Source dataset
- uspto-grants-2013_07
- Patent number
- US08481732B2
Reaction notes
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