Hydrochloric Acid → 2-(6-chloropyridin-3-yl)-N-ethylpropan-2-amine
Reaction equation
[Cl:1][C:2]1[N:7]=[CH:6][C:5]([C:8]([NH:11][C:12](=O)[CH3:13])([CH3:10])[CH3:9])=[CH:4][CH:3]=1.Cl>C1COCC1>[Cl:1][C:2]1[N:7]=[CH:6][C:5]([C:8]([NH:11][CH2:12][CH3:13])([CH3:9])[CH3:10])=[CH:4][CH:3]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
N-(2-(6-chloropyridin-3-yl)propan-2-yl)acetamide (11.3 g, 53.1 mmol, Eq: 1.00) was dissolved in anhydrous THF (350 ml) and refluxed. BMS (2M in THF) (53.1 ml, 106 mmol, Eq: 2) was added dropwise to the solution and refluxed over night. Conc. HCl solution (15 ml) was gently added to the refluxed reaction mixture and stirred for 1 hr. The reaction mixture was concentrated in vacuo.
Workup
- temperaturerefluxed
- temperaturerefluxed over night
- concentrationThe reaction mixture was concentrated in vacuo
Sources & evidence
- ORD record
- ord-876ca2c6029a488da2cf414671c55155
- Source dataset
- uspto-grants-2013_07
- Patent number
- US08481540B2
Reaction notes
Loading…