p-Bromoacetophenone → 4-Bromophenacyl bromide

Temperature

60 °C

Into a 250-mL 3-necked round-bottom flask, was placed a solution of 1-(4-bromophenyl)ethanone (10.0 g, 50.25 mmol, 1.00 equiv) in acetic acid (50 mL). This was followed by the addition of a solution of bromine (8.2 g, 1.05 equiv) in acetic acid (50 mL) dropwise with stirring at 60° C. over 90 min. The resulting solution was stirred for 3 h at 60° C. The resulting mixture was concentrated under vacuum. The crude product was re-crystallized from petroleum ether/ethyl acetate in the ratio of 7:1. This resulted in 9.3 g (67%) of the title compound as a yellow solid.

1. customInto a 250-mL 3-necked round-bottom flask, was placed
2. stirringThe resulting solution was stirred for 3 h at 60° C
3. concentrationThe resulting mixture was concentrated under vacuum
4. customThe crude product was re-crystallized from petroleum ether/ethyl acetate in the ratio of 7:1

ORD record

ord-531419fd15e1467baf639234e50ceeb9

Source dataset

uspto-grants-2013_09

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08541448B2