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Hydrochloric Acid → 3,4-bis-(4-methoxyphenyl)-5-ethyl-4H-1,2,4-triazole hydrochloride

HRID 4594
Notes
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Reaction equation

HRID 4594 reaction equation
[ClH:1].[CH3:2][O:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[N:14]([C:15]3[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][CH:16]=3)[C:13]([CH2:23][CH3:24])=[N:12][N:11]=2)=[CH:6][CH:5]=1.C(OC(C)C)(C)C>C(O)C>[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[CH:6][C:7]([C:10]2[N:14]([C:15]3[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][CH:16]=3)[C:13]([CH2:23][CH3:24])=[N:12][N:11]=2)=[CH:8][CH:9]=1
ParticipantsProcedureWorkupSources & evidenceReaction notes

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 7914Diisopropyl EtherHCID 130540183,4-bis-(4-methoxyphenyl)-5-ethyl-4H-1,2,4-triazole

Product 1

HCID 201515453,4-bis-(4-methoxyphenyl)-5-ethyl-4H-1,2,4-triazole hydrochloride

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

2.9 ml of a solution of 5.9N hydrogen chloride in ethanol were aded to a solution of 5 g of the product of Example 1 in 5 ml of ethanol and the mixture was stirred while adding isopropyl ether thereto. The mixture was stirred for 24 hours and was filtered. The product was empasted with isopropyl ether, filtered and dried under pressure to obtain 4.4 g of 3,4-bis-(4-methoxyphenyl)-5-ethyl-4H-1,2,4-triazole hydrochloride.

Workup

  1. stirringThe mixture was stirred for 24 hours
  2. filtrationwas filtered
  3. filtrationfiltered
  4. customdried under pressure

Sources & evidence

ORD record
ord-29c1287a74224764a2342d6da5b34f12
Source dataset
uspto-grants-1988_02
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US04727084

Reaction notes

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On this pageParticipantsProcedureWorkupSources & evidenceReaction notes