Water → HCID 23712812, compound
Reaction equation
O.[OH-].[Li+:3].C[O:5][C:6]([C:8]1[O:9][C:10]2[CH2:11][N:12]([CH3:17])[CH2:13][CH2:14][C:15]=2[N:16]=1)=[O:7]>O1CCCC1>[CH3:17][N:12]1[CH2:13][CH2:14][C:15]2[N:16]=[C:8]([C:6]([O-:7])=[O:5])[O:9][C:10]=2[CH2:11]1.[Li+:3]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
Water (6.0 ml) and lithium hydroxide (99.7 mg) were added to a solution of 2-methoxycarbonyl-5-methyl-4,5,6,7-tetrahydrooxazolo[5,4-c]pyridine (800 mg) in tetrahydrofuran (24 ml) at room temperature, and the mixture was stirred for 10 minutes. The reaction mixture was concentrated under reduced pressure to obtain the title compound (825 mg).
Workup
- concentrationThe reaction mixture was concentrated under reduced pressure
Sources & evidence
- ORD record
- ord-2fb317a880104a709680ef255a5ac435
- Source dataset
- uspto-grants-2007_03
- Patent number
- US07192968B2
Reaction notes
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