Dimethylamine → 2-(Aminomethylidene)-2,3-dihydro-1h-inden-1-one

HRID 461879

Reaction equation

HRID 461879 reaction equation
O[CH:2]=[C:3]1[CH2:11][C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]1=[O:12].C([O-])(=O)C.[NH4+].C[NH:19]C.CN.NC(O)C>C(O)C>[NH2:19][CH:2]=[C:3]1[CH2:11][C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]1=[O:12]

Participants

7

Reactant 5

HCID 674DimethylamineHCID 6329MethylamineHCID 517165Ammonium AcetateHCID 522583Acetaldehyde ammoniaHCID 37648821H-Inden-1-one, 2,3-dihydro-2-(hydroxymethylene)-

Product 1

HCID 1703122-(Aminomethylidene)-2,3-dihydro-1h-inden-1-one

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The 2-hydroxymethylene-1-indanone is then reacted with the appropriate nitrogen compound e.g. ammonium acetate, dimethyl amine, monomethyl amine or aminoethanol, in ethanol or any other suitable solvent to yield a 2-aminomethylene-1-indanone which is then dried and recrystallized from benzene or any other suitable solvent.

Sources & evidence

ORD record
ord-b97509e6123d49ed954cf3584c3785b7
Source dataset
uspto-grants-1977_12
Patent number
US04064272

Linked notes

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