Phosphorus oxychloride → N-Methyl-N'-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]1,3,4-oxadiazole-2,5-diamine

HRID 4632

Reaction equation

[CH3:1][NH:2][C:3]([NH:5][NH:6][C:7]([NH:9][CH2:10][CH2:11][CH2:12][O:13][C:14]1[CH:19]=[CH:18][CH:17]=[C:16]([CH2:20][N:21]2[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]2)[CH:15]=1)=[O:8])=O.P(Cl)(Cl)(Cl)=O>>[CH3:1][NH:2][C:3]1[O:8][C:7]([NH:9][CH2:10][CH2:11][CH2:12][O:13][C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([CH2:20][N:21]3[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]3)[CH:15]=2)=[N:6][N:5]=1

Participants

Reactant 2

HCID 24813Phosphorus oxychloride

HCID 13657347N-Methyl-N'-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]1,2-hydrazine dicarboxamide

Product 1

HCID 13657370N-Methyl-N'-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]1,3,4-oxadiazole-2,5-diamine

Procedure

The compound is prepared by a method analogous to that of Example 40 from N-methyl-N'-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]-1,2-hydrazine dicarboxamide and phosphorus oxychloride. The analytical values are summarized in Table III.

Sources & evidence

ORD record: ord-971b8e9f32ef4c168ef57c971277054d
Source dataset: uspto-grants-1988_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04727081

Linked notes

Loading…