4-Chlorobutanoic acid → Gamma-Butyrolactone

HRID 463563

Reaction equation

HRID 463563 reaction equation
Cl[CH2:2][CH2:3][CH2:4][C:5]([OH:7])=[O:6].[OH-].[K+]>>[CH:4]1([C:5]([OH:7])=[O:6])[CH2:2][CH2:3]1.[C:5]1(=[O:7])[O:6][CH2:2][CH2:3][CH2:4]1

Participants

4

Reactant 2

HCID 123004-Chlorobutanoic acidHCID 14797Potassium Hydroxide

Product 2

HCID 7302Gamma-ButyrolactoneHCID 15655Cyclopropanecarboxylic acid

Procedure

It is known to condense the ethyl ester of 4-chlorobutyric acid with aqueous potassium hydroxide on pumice. There is obtained thereby in moderate yield the ethyl ester of cyclopropane carboxylic acid besides the free acid and γ-butyrolactone (Rambaud, BL. [5] (1938), pages 1552, 1564).

Workup

  1. customThere is obtained

Sources & evidence

ORD record
ord-036e0e2f002e418d8ac86ca239b78336
Source dataset
uspto-grants-1985_05
Patent number
US04520209

Linked notes

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