Benzaldehyde → Cyano(phenyl)methyl 2-methylpropanoate

HRID 46753

Reaction equation

HRID 46753 reaction equation
[C:1]([O:6][C:7](=[O:11])[CH:8]([CH3:10])[CH3:9])(=O)[CH:2]([CH3:4])[CH3:3].[CH:12](=O)[C:13]1[CH:18]=CC=CC=1.[C-:20]#[N:21].[Na+]>O>[C:7]([O:6][CH:1]([C:20]#[N:21])[C:2]1[CH:4]=[CH:18][CH:13]=[CH:12][CH:3]=1)(=[O:11])[CH:8]([CH3:10])[CH3:9]

Participants

5

Reactant 3

HCID 240BenzaldehydeHCID 7346Isobutyric anhydrideHCID 8929Sodium Cyanide

Product 1

HCID 13536647Cyano(phenyl)methyl 2-methylpropanoate

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
25 °C

Procedure

A 100-ml round-bottomed flask equipped with a magnetic stirrer was charged with isobutyric anhydride (10 mmol), benzaldehyde (10 mmol), a mixture of alkanes (25 ml) having a boiling range of from 62° C. to 82° C., sodium cyanide (12 mmol) and water (3 ml). The mixture formed was stirred at a temperature of 25° C. The table presents the yields of the title ester after the reaction times indicated (Embodiment IV).

Workup

  1. customA 100-ml round-bottomed flask equipped with a magnetic stirrer
  2. customThe mixture formed

Sources & evidence

ORD record
ord-b8b0d7af08bb45c5b88e08b5a8efd0a7
Source dataset
uspto-grants-1979_11
Patent number
US04175094

Linked notes

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