1,1'-Carbonyldiimidazole → HCID 58393370, compound

HRID 469009Notes

Reaction equation

HRID 469009 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([CH3:9])[C:6]([S:10]([N:13]([CH2:15][C:16]2[O:20][CH:19]=[C:18]([C:21](O)=[O:22])[CH:17]=2)[CH3:14])(=[O:12])=[O:11])=[C:5]([CH3:24])[CH:4]=1.C1N=CN(C(N2C=NC=C2)=O)C=1.[CH3:37][N:38]1[CH2:43][CH2:42][CH2:41][CH:40]([CH2:44][N:45]2[CH2:50][CH2:49][NH:48][CH2:47][CH2:46]2)[CH2:39]1>ClCCCl>[CH3:1][O:2][C:3]1[CH:8]=[C:7]([CH3:9])[C:6]([S:10]([N:13]([CH3:14])[CH2:15][C:16]2[O:20][CH:19]=[C:18]([C:21]([N:48]3[CH2:47][CH2:46][N:45]([CH2:44][CH:40]4[CH2:41][CH2:42][CH2:43][N:38]([CH3:37])[CH2:39]4)[CH2:50][CH2:49]3)=[O:22])[CH:17]=2)(=[O:12])=[O:11])=[C:5]([CH3:24])[CH:4]=1

Participants

5

Reactant 3

HCID 682631,1'-CarbonyldiimidazoleHCID 27369401-[(1-Methylpiperidin-3-yl)methyl]piperazineHCID 583930975-({[(4-Methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)furan-3-carboxylic acid

Product 1

HCID 58393370HCID 58393370, compound

Reagents, catalysts & solvents 1

HCID 111,2-DichloroethaneSolvent

Procedure

The title compound was prepared according to general procedure AA using 5-({[(4-Methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)furan-3-carboxylic acid (63 mg, 0.18 mmol), CDI (58 mg, 0.36 mmol) and 1-[(1-methylpiperidin-3-yl)methyl]piperazine (59 mg, 0.30 mmol) in DCE (4.5 mL).

Sources & evidence

ORD record
ord-12c3708168c54286950ca2dadbab041e
Source dataset
uspto-grants-2014_01
Patent number
US08623859B2

Reaction notes

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