F[C:2]1[CH:3]=[C:4]([CH2:19][CH2:20][OH:21])[CH:5]=[CH:6][C:7]=1[O:8][C:9]1[CH:10]=NC(C(F)(F)F)=N[CH:14]=1.[N:22]#[C:23][NH2:24].OS([C:29]([F:32])(F)F)(=O)=O.[CH2:33]1[CH2:37]OC[CH2:34]1>>[C:23](=[NH:24])([O:21][CH2:20][CH2:19][C:4]1[CH:3]=[CH:2][C:7]([O:8][C:9]2[CH:14]=[CH:34][C:33]([CH3:37])=[C:29]([F:32])[CH:10]=2)=[CH:6][CH:5]=1)[NH2:22]To a solution of 2-(3-fluoro-4-((2-(trifluoromethyl)pyrimidin-5-yl)oxy)phenyl)ethanol (756 mg, 1.251 mmol) and cyanamide (105 mg, 2.501 mmol) in dry THF (6 mL) under nitrogen was added triflic acid (0.222 mL, 2.501 mmol). The mixture was heated at 55° C. for 3 h. Purification via reverse phase flash chromatography afforded the title compound (1 g, 2.104 mmol, 24.95% yield). LCMS: rt=2.41 min, [M+H+]=345
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