Ammonia → 2-Amino-1-phenoxy-propene

HRID 476874Notes

Reaction equation

HRID 476874 reaction equation
[O:1]([CH2:8][C:9](=O)[CH3:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH3:12].C1(C)C=CC(S(O)(=O)=O)=CC=1>O1CCCC1>[NH2:12][C:9]([CH3:10])=[CH:8][O:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 222AmmoniaHCID 6101p-Toluenesulfonic acidHCID 693131-Phenoxy-2-propanone

Product 1

HCID 700488602-Amino-1-phenoxy-propene

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

0.2 mol of phenoxyacetone in 200 ml of tetrahydrofuran is saturated at reflux temperature with ammonia gas with the addition of 0.2 g of p-toluene sulphonic acid. The mixture is allowed to stand at room temperature for 24 hours and the solvent is then removed by evaporation in vacuo. The evaporation residue is employed crude in the reaction of Example 5B.

Workup

  1. customthe solvent is then removed by evaporation in vacuo
  2. customin the reaction of Example 5B

Sources & evidence

ORD record
ord-f9508f221bf3480cacb1d5f539bc49be
Source dataset
uspto-grants-1989_12
Patent number
US04886804

Reaction notes

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