Triethylamine → 2-Nitro-5-(4-acetylamino-1-piperidyl)benzaldehyde dimethylacetal

HRID 477178

Reaction equation

HRID 477178 reaction equation
[CH3:1][O:2][CH:3]([O:14][CH3:15])[C:4]1[CH:9]=[C:8](Cl)[CH:7]=[CH:6][C:5]=1[N+:11]([O-:13])=[O:12].Cl.[C:17]([NH:20][CH:21]1[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1)(=[O:19])[CH3:18].C(=O)([O-])[O-].[Na+].[Na+].C(N(CC)CC)C>CN1CCCC1=O.C(OCC)C>[CH3:1][O:2][CH:3]([O:14][CH3:15])[C:4]1[CH:9]=[C:8]([N:24]2[CH2:25][CH2:26][CH:21]([NH:20][C:17](=[O:19])[CH3:18])[CH2:22][CH2:23]2)[CH:7]=[CH:6][C:5]=1[N+:11]([O-:13])=[O:12]

Participants

7

Reactant 4

HCID 8471TriethylamineHCID 10340Sodium CarbonateHCID 35700934-Chloro-2-(dimethoxymethyl)-1-nitrobenzeneHCID 114011054-Acetamidopiperidine dihydrochloride

Product 1

HCID 190868632-Nitro-5-(4-acetylamino-1-piperidyl)benzaldehyde dimethylacetal

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 13387N-methyl-2-pyrrolidoneSolvent

Conditions

Temperature
120 °C

Procedure

12 Grams of 2-nitro-5-chlorobenzaldehyde dimethyl acetal, 16.3 g of 4-acetylaminopiperidine hydrochloride, 13.7 g of sodium carbonate and 13 ml of triethylamine in 150 ml of N-methylpyrrolidone solution were mixed together and reacted by heating at 120° C. for 12 hours with stirring under nitrogen gas stream. After the reaction was completed, the solvent was removed by evaporation and thus obtained residue was added with water and extracted with dichloromethane, then the extract was washed with water and with an aqueous solution saturated with sodium chloride, then dried with anhydrous sodium sulfate. The solvent was removed by evaporation and the residue thus obtained was added with diethyl ether, then the crystals formed were collected by filtration to yield 11.2 g of 2-nitro-5-(4-acetylamino-1-piperidyl)benzaldehyde dimethylacetal.

Workup

  1. customreacted
  2. customthe solvent was removed by evaporation and thus obtained residue
  3. additionwas added with water
  4. extractionextracted with dichloromethane
  5. washthe extract was washed with water and with an aqueous solution saturated with sodium chloride
  6. dry with materialdried with anhydrous sodium sulfate
  7. customThe solvent was removed by evaporation
  8. customthe residue thus obtained
  9. customthe crystals formed
  10. filtrationwere collected by filtration

Sources & evidence

ORD record
ord-67b3db273b304161b3597310c64abb49
Source dataset
uspto-grants-1989_12
Patent number
US04886809

Linked notes

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