4-Piperidone → 1-(Cyclopropylmethyl)piperidin-4-one

Reaction equation

[NH:1]1[CH2:6][CH2:5][C:4](=[O:7])[CH2:3][CH2:2]1.Cl[CH2:9][CH:10]1[CH2:12][CH2:11]1>>[CH:10]1([CH2:9][N:1]2[CH2:6][CH2:5][C:4](=[O:7])[CH2:3][CH2:2]2)[CH2:12][CH2:11]1

Participants

Reactant 2

HCID 337214-Piperidone

HCID 80013(Chloromethyl)cyclopropane

Product 1

HCID 180021811-(Cyclopropylmethyl)piperidin-4-one

Procedure

1-(Cyclopropylmethyl)-4-piperidone is prepared from 4-piperidone and (chloromethyl)cyclopropane essentially as described above in Example 38, Scheme C, step a.

Sources & evidence

ORD record: ord-0913f2031bb146b2a8f02e3f62cd072e
Source dataset: uspto-grants-2003_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06642231B2

Reaction notes

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