1,4-Dioxa-8-azaspiro(4.5)decane → 8-(6-Methoxy-2-pyridinyl)-1,4-dioxa-8-azaspiro[4.5]decane

HRID 480

Reaction equation

HRID 480 reaction equation
C1CC2(CCN1)OCCO2.COc1cccc(Br)n1>CC(=O)O.CC(=O)O.CC(C)(C)[O-].CC(C)c1cc(C(C)C)c(-c2ccccc2P(C2CCCCC2)C2CCCCC2)c(C(C)C)c1.[Na+].[Pd]>COc1cccc(N2CCC3(CC2)OCCO3)n1

Participants

6

Reactant 2

HCID 674351,4-Dioxa-8-azaspiro(4.5)decaneHCID 2568102-Bromo-6-methoxypyridine

Product 1

HCID 815811468-(6-Methoxy-2-pyridinyl)-1,4-dioxa-8-azaspiro[4.5]decaneYield 69.11%

Reagents, catalysts & solvents 3

HCID 23676156Sodium t-butoxideReagentHCID 4144353Palladium (II) acetateCatalystHCID 111557942-Dicyclohexylphosphino-2',4',6'-triisoprophylbiphenylCatalyst

Procedure

The same procedure as EN03653-93-01.

Sources & evidence

ORD record
ord-74d98b785957480d946a0d3ab89bccf5
Source dataset
750 AstraZeneca ELN dataset
Original link
View source

Linked notes

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