Ammonium Chloride → HCID 178507487, compound

HRID 49416

Reaction equation

HRID 49416 reaction equation
[NH2:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[C:4]#[N:5].[N-:10]=[N+:11]=[N-:12].[Na+].[Cl-].[NH4+]>CN(C)C=O>[NH2:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[C:4]1[NH:12][N:11]=[N:10][N:5]=1

Participants

5

Reactant 3

HCID 25517Ammonium ChlorideHCID 33557Sodium AzideHCID 729132-Aminobenzonitrile

Product 1

HCID 178507487HCID 178507487, compoundYield 65.2%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
120 °C

Procedure

2-Aminobenzonitrile (9.44 g, 80 mmol), sodium azide, (6.24 g, 0.1 mol), ammonium chloride (5.12 g, 0.1 mol) and dimethylformamide (50 mL) were mixed and heated at 120° C. overnight. The solvent was evaporated and the residue taken up in water. The crude product was isolated by filtration and re-crystallised from water. A yield of 8.4 g of pure product was obtained.

Workup

  1. customThe solvent was evaporated
  2. customThe crude product was isolated by filtration
  3. customre-crystallised from water

Sources & evidence

ORD record
ord-a936d3f8745246b09e090948dd60efc6
Source dataset
uspto-grants-2004_03
Patent number
US06706749B2

Linked notes

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