Lithium hydroxide, monohydrate → HCID 178524764, compound

Ethyl 4-hydroxypyrimidine-5-carboxylate can be prepared following the procedure of M. Pesson et al., Eur. J. Med. Chem.—Chim. Ther. 1974, 9, 585. A solution of this ester (500 mg, 3 mmol) in THF (10 mL) and MeOH (5 mL) was treated with LiOH.H2O (373 mg, 8.9 mmol) and stirred overnight. The mixture was quenched with conc. HCl (1 mL) and extracted with EtOAc (2×20 mL). The combined organic extract was dried (MgSO4) and concentrated to give 260 mg of the title compound 19 as an orange solid, m.p. 220° C. (dec).

1. customThe mixture was quenched with conc. HCl (1 mL)
2. extractionextracted with EtOAc (2×20 mL)
3. extractionThe combined organic extract
4. dry with materialwas dried (MgSO4)
5. concentrationconcentrated

ORD record

ord-30d401e6ff654e68b9089c32871ed5bd

Source dataset

uspto-grants-2004_03

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06706740B2