4-Bromo-2-chloroaniline → 4-(4-Bromo-2-chlorophenylamino)-6-chloronicotinic acid hydrochloride salt

HRID 494696

Reaction equation

HRID 494696 reaction equation
[Li+].C[Si]([N-][Si](C)(C)C)(C)C.[Br:11][C:12]1[CH:17]=[CH:16][C:15]([NH2:18])=[C:14]([Cl:19])[CH:13]=1.Cl[C:21]1[C:26]([C:27]([OH:29])=[O:28])=[CH:25][N:24]=[C:23]([Cl:30])[CH:22]=1>C1COCC1>[ClH:19].[Br:11][C:12]1[CH:17]=[CH:16][C:15]([NH:18][C:21]2[C:26]([C:27]([OH:29])=[O:28])=[CH:25][N:24]=[C:23]([Cl:30])[CH:22]=2)=[C:14]([Cl:19])[CH:13]=1

Participants

5

Reactant 3

HCID 6101694-Bromo-2-chloroanilineHCID 8171584,6-Dichloronicotinic acidHCID 2733832Lithium Hexamethyldisilazide

Product 1

HCID 865967774-(4-Bromo-2-chlorophenylamino)-6-chloronicotinic acid hydrochloride salt

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

LiHMDS (261 mL of a 1 M solution in hexanes) was added dropwise over 30 minutes to a solution of 4-bromo-2-chlorophenylamine (35.0 g, 172 mmol) in THF (80 mL) at −78° C. After 1 hour, 4,6-dichloronicotinic acid (23) (15.7 g, 81.7 mmol) was added dropwise over 30 minutes. The reaction mixture was slowly warmed to room temperature and stirred 16 hours. The reaction mixture was quenched with water, diluted with EtOAc and acidified with 1 M HCl. The resulting precipitate was isolated by filtration and washed with EtOAc. The solids were twice concentrated from toluene, triturated with CH2Cl2 and collected by filtration. The solids were further concentrated from toluene (3×) followed by drying in vacuo to give the desired product (24) containing a small amount of water (36.0 g).

Workup

  1. customThe reaction mixture was quenched with water
  2. additiondiluted with EtOAc
  3. customThe resulting precipitate was isolated by filtration
  4. washwashed with EtOAc
  5. concentrationThe solids were twice concentrated from toluene
  6. customtriturated with CH2Cl2
  7. filtrationcollected by filtration
  8. concentrationThe solids were further concentrated from toluene (3×)
  9. customby drying in vacuo

Sources & evidence

ORD record
ord-38829f9580374c3ab8477ac18b7e7191
Source dataset
uspto-grants-2009_05
Patent number
US07538120B2

Linked notes

Loading…