1,1'-Carbonyldiimidazole → 1-(1-Azabicyclo[2.2.2]oct-3-yl)-3-(3-chlorophenyl)-imidazolidin-2-one hydrochloride

HRID 4951

Reaction equation

HRID 4951 reaction equation
[N:1]12[CH2:8][CH2:7][CH:4]([CH2:5][CH2:6]1)[CH:3]([NH:9][CH2:10][CH2:11][NH:12][C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([Cl:19])[CH:14]=1)[CH2:2]2.C1N=CN([C:25](N2C=NC=C2)=[O:26])C=1>O1CCCC1>[ClH:19].[N:1]12[CH2:6][CH2:5][CH:4]([CH2:7][CH2:8]1)[CH:3]([N:9]1[CH2:10][CH2:11][N:12]([C:13]3[CH:18]=[CH:17][CH:16]=[C:15]([Cl:19])[CH:14]=3)[C:25]1=[O:26])[CH2:2]2

Participants

4

Reactant 2

HCID 682631,1'-CarbonyldiimidazoleHCID 10492977N-(1-azabicyclo[2.2.2]oct-3 yl)-N'-(3-chlorphenyl)-1,2-diaminoethane

Product 1

HCID 200819261-(1-Azabicyclo[2.2.2]oct-3-yl)-3-(3-chlorophenyl)-imidazolidin-2-one hydrochloride

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a stirred solution of N-(1-azabicyclo[2.2.2]oct-3 yl)-N'-(3-chlorphenyl)-1,2-diaminoethane (2.7 g; 0.0097 moles) in anhydrous tetrahydrofuran (10 ml), N,N-carbonyldiimidazole (2.04 g; 0.0125 moles) is added.

Sources & evidence

ORD record
ord-14c963ad2f0d4f1db8384f9ea0e1f629
Source dataset
uspto-grants-1993_09
Patent number
US05242929

Linked notes

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