Potassium Carbonate → [4-(1,4-Benzodioxan-5-yl)-1,2,3,6-tetrahydropyrid-1-yl]acetonitrile

HRID 4972

Reaction equation

HRID 4972 reaction equation
C(=O)([O-])[O-].[K+].[K+].Br[CH2:8][C:9]#[N:10].Cl.[O:12]1[C:17]2[CH:18]=[CH:19][CH:20]=[C:21]([C:22]3[CH2:23][CH2:24][NH:25][CH2:26][CH:27]=3)[C:16]=2[O:15][CH2:14][CH2:13]1>CC(C)=O>[O:12]1[C:17]2[CH:18]=[CH:19][CH:20]=[C:21]([C:22]3[CH2:23][CH2:24][N:25]([CH2:8][C:9]#[N:10])[CH2:26][CH:27]=3)[C:16]=2[O:15][CH2:14][CH2:13]1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 11534BromoacetonitrileHCID 190962384-[(1,4-Benzodioxan-5-yl)]-1,2,3,6-tetrahydropyridine hydrochloride

Product 1

HCID 19105274[4-(1,4-Benzodioxan-5-yl)-1,2,3,6-tetrahydropyrid-1-yl]acetonitrile

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent2×

Procedure

2.5 g of potassium carbonate and, dropwise, a solution of 1.08 g of bromoacetonitrile in 10 ml of acetone are added to a solution of 1.9 g of the amine hydrochloride obtained in Stage B in 40 ml of acetone.

Sources & evidence

ORD record
ord-8836235aef454333bcb8b379cc7831d3
Source dataset
uspto-grants-1993_09
Patent number
US05242933

Linked notes

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