2-Methylpyrrolidine → Bis(2-Methoxyethyl)amine

Reaction equation

[OH:1][CH2:2]C1CCCN1.CC1CCCN1.[CH3:14][O:15][CH2:16][CH:17]1C[CH2:20][CH2:19][NH:18]1.N1CCC[C@H]1C(O)=O.CC1NC(C)CNC1>>[CH3:2][O:1][CH2:20][CH2:19][NH:18][CH2:17][CH2:16][O:15][CH3:14]

Participants

Reactant 5

HCID 130032-Methylpyrrolidine

HCID 660562,6-Dimethylpiperazine

HCID 90908Prolinol

HCID 1439532-(Methoxymethyl)pyrrolidine

HCID 145742L-Proline

Product 1

HCID 2383Bis(2-Methoxyethyl)amine

Procedure

Following the procedure described above, but substituting pyrrolidine with 2-hydroxymethylpyrrolidine, 2-methylpyrrolidine, 2-methoxymethylpyrrolidine, proline, 3,5-dimethylpiperazine, an bis-(2-methoxyethyl)amine provide:

Sources & evidence

ORD record: ord-3a3ac0903e744d25b8303f51e43178d9
Source dataset: uspto-grants-2004_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06710067B2

Reaction notes

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