Sodium → 5-Methyl-6-oxoheptanesulfonic acid

HRID 500094

Reaction equation

HRID 500094 reaction equation
C(O[C:4]([C:6](C)([C:15](=[O:17])[CH3:16])[CH2:7][CH2:8][CH2:9][CH2:10][S:11]([O-:14])(=[O:13])=[O:12])=O)C.[Na]>Cl>[CH3:4][CH:6]([C:15](=[O:17])[CH3:16])[CH2:7][CH2:8][CH2:9][CH2:10][S:11]([OH:14])(=[O:12])=[O:13]

Participants

4

Reactant 2

HCID 5360545SodiumHCID 594224655-(Ethoxycarbonyl)-5-methyl-6-oxoheptane-1-sulphonate

Product 1

HCID 579033515-Methyl-6-oxoheptanesulfonic acid

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

5-(Ethoxycarbonyl)-5-methyl-6-oxoheptane-1-sulphonate, sodium salt (from 1.1) was heated at 90° C. in concentrated hydrochloric acid (200 ml), until TLC indicated complete reaction (˜3 hrs). The solvent was then evaporated under vacuum; the residue was purified by flash chromatography (Silica. Ethanol/dichloromethane mixtures) to give 49.6 g of 5-methyl-6-oxoheptane-1-sulphonic acid.

Workup

  1. customreaction (˜3 hrs)
  2. customThe solvent was then evaporated under vacuum
  3. customthe residue was purified by flash chromatography (Silica. Ethanol/dichloromethane mixtures)

Sources & evidence

ORD record
ord-d343bf7b98de416fb47c01395140dd59
Source dataset
uspto-grants-2010_08
Patent number
US07767829B2

Linked notes

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