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1,2-Dichloroethane → HCID 178519697, compound

HRID 507925
Notes
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Reaction equation

HRID 507925 reaction equation
[C:1]1([C:7]2[N:8]=[C:9]([CH:12]=O)[S:10][CH:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:14][C:15]1[CH:20]=[CH:19][C:18]([CH2:21][OH:22])=[CH:17][CH:16]=1.C(O)(=O)C.ClCCCl>CCCCCC>[C:1]1([C:7]2[N:8]=[C:9](/[CH:12]=[N:14]/[C:15]3[CH:20]=[CH:19][C:18]([CH2:21][OH:22])=[CH:17][CH:16]=3)[S:10][CH:11]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1
ParticipantsProcedureWorkupSources & evidenceReaction notes

Participants

6

Reactant 4

HCID 111,2-DichloroethaneHCID 176Acetic AcidHCID 693314-Aminobenzyl alcoholHCID 35388144-Phenyl-1,3-thiazole-2-carbaldehyde

Product 1

HCID 178519697HCID 178519697, compoundYield 88.3%

Reagents, catalysts & solvents 1

HCID 8058
Hexane
Solvent

Procedure

A mixture of 4-phenyl-1,3-thiazole-2-carbaldehyde (1.10 g, 5.81 mmol), (4-aminophenyl)methanol (615 mg, 5.0 mmol), acetic acid (0.4 mL) and 1,2-dichloroethane (10 mL) was stirred at room temperature for 30 min. The reaction mixture was diluted with hexane. The precipitated solid was collected by filtration, washed with hexane, and dried to give the title compound (1.30 g, yield 88%) as yellow crystals.

Workup

  1. filtrationThe precipitated solid was collected by filtration
  2. washwashed with hexane
  3. customdried

Sources & evidence

ORD record
ord-c030fbe8d23e465e8c1700c584484805
Source dataset
uspto-grants-2010_08
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US07786165B2

Reaction notes

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On this pageParticipantsProcedureWorkupSources & evidenceReaction notes