Ethanolamine → 2,4-difluoro-N-(2-hydroxyethyl)benzamide

Temperature

0 °C

To a solution of ethanolamine (1.10 g, 15.8 mmol) in THF at 0° C. under N2 was added 2,4-difluorobenzoyl chloride (500 mg, 2.83 mmol). The reaction mixture was stirred at 0° C. for 4 h, then diluted with ethyl acetate (100 mL) and washed with 1 N HCl (50 mL), saturated NaHCO3 (50 mL), and saturated NaCl (50 mL). The organic solution was dried over MgSO4 and concentrated in vacuo to yield 2,4-difluoro-N-(2-hydroxyethyl)benzamide as a white solid (495 mg, 87%).

1. washwashed with 1 N HCl (50 mL), saturated NaHCO3 (50 mL), and saturated NaCl (50 mL)
2. dry with materialThe organic solution was dried over MgSO4
3. concentrationconcentrated in vacuo

ORD record

ord-084e64c90f2c4f3cbc32025195d73cff

Source dataset

uspto-grants-2004_03

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06713471B1