Hydroxylamine → 4-Phenylcyclohexanone oxime
Reaction equation
[C:1]1([CH:7]2[CH2:12][CH2:11][C:10](=O)[CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:14][OH:15].O>C(O)C>[C:1]1([CH:7]2[CH2:12][CH2:11][C:10](=[N:14][OH:15])[CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
To a solution of 4-phenylcyclohexanone (1.50 g, 8.609 mmol) in 95% ethanol (20 ml) was added 50% hydroxylamine in water (5.276 ml, 86.09 mmol), and the reaction was heated to reflux for 1 hour. The reaction was allowed to cool to ambient temperature, and the product was precipitated by the slow addition of water. The solids were collected via filtration to yield 1.0 g of the title compound (61.38% yield).
Workup
- temperaturethe reaction was heated
- temperatureto reflux for 1 hour
- customthe product was precipitated by the slow addition of water
- filtrationThe solids were collected via filtration
Sources & evidence
- ORD record
- ord-b58103c0762d46d8bfb51620daad589c
- Source dataset
- uspto-grants-2015_08
- Patent number
- US09096567B2
Reaction notes
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