Dimethylformamide → 2-Chloro-3-(trifluoromethyl)benzoyl chloride
Reaction equation
[Cl:1][C:2]1[C:10]([C:11]([F:14])([F:13])[F:12])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4](O)=[O:5].CN(C=O)C.C(Cl)(=O)C([Cl:23])=O>C(Cl)Cl>[Cl:1][C:2]1[C:10]([C:11]([F:14])([F:13])[F:12])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([Cl:23])=[O:5]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
To a suspension of 2-chloro-3-(trifluoromethyl)benzoic acid (15 g, 67 mmol) and catalytic DMF (0.06 mL, 0.67 mmol) in DCM (150 mL) was added oxalyl chloride (6.8 mL, 80 mmol) dropwise. The reaction was let stir (vigorous bubbling) for 4 h and concentrated to an oily solid which became solid after overnight drying on high vacuum.
Workup
- custom(vigorous bubbling) for 4 h
- concentrationconcentrated to an oily solid which
- customafter overnight
- customdrying on high vacuum
Sources & evidence
- ORD record
- ord-7e8ac219a9984f6494b1041233e4e050
- Source dataset
- uspto-grants-2015_08
- Patent number
- US09102686B2
Reaction notes
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