Hydrochloric Acid → HCID 178479550, compound

HRID 514674

Reaction equation

HRID 514674 reaction equation
[NH2:1][CH:2]([C:6]([NH2:8])=[O:7])[C:3]([NH2:5])=[O:4].[CH:9](OCC)(OCC)[O:10]CC.CC(O)C.[ClH:23]>O>[OH2:4].[OH2:10].[ClH:23].[OH:4][C:3]1[NH:5][CH:9]=[N:1][C:2]=1[C:6]([NH2:8])=[O:7]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 3776IsopropanolHCID 31214Ethyl orthoformateHCID 964572-Aminopropanediamide

Product 1

HCID 178479550HCID 178479550, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Conditions

Temperature
80 °C

Procedure

Under the nitrogen atmosphere, 10 g of 2-aminomalonamide and 35.4 mL of triethyl orthoformate were added to 200 mL of 2-propanol. After heating to 80° C., the reaction mixture was stirred for 8 hours at the same temperature. Color of the reaction liquid was pale yellow when the reaction was completed. Subsequently, after cooling to 57° C., the reaction mixture was added with 10 mL of water followed by 8 mL of conc. hydrochloric acid. After cooling with water, the crystal was collected by filtration and then washed with 40 mL of acetone to give 16 g of 5-hydroxy-1H-imidazole-4-carboxamide hydrochloric acid salt dihydrate as a pale yellow crystal.

Workup

  1. customColor of the reaction liquid
  2. temperatureSubsequently, after cooling to 57° C.
  3. filtrationthe crystal was collected by filtration
  4. washwashed with 40 mL of acetone

Sources & evidence

ORD record
ord-8487a73d06d44a57b723f3e05a7389e4
Source dataset
uspto-grants-2015_08
Patent number
US09108928B2

Linked notes

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