Hydrochloric Acid → HCID 178479550, compound

Temperature

80 °C

Under the nitrogen atmosphere, 10 g of 2-aminomalonamide and 35.4 mL of triethyl orthoformate were added to 200 mL of 2-propanol. After heating to 80° C., the reaction mixture was stirred for 13 hours at the same temperature. Color of the reaction liquid was pale blue when the reaction was completed. Subsequently, the reaction mixture was cooled to 58° C., then added with 10 mL of water followed by 8 mL of conc. hydrochloric acid. After cooling the reaction mixture to 5° C., the crystal was collected by filtration and then washed with 40 mL of acetone to give 16 g of 5-hydroxy-1H-imidazole-4-carboxamide hydrochloric acid salt dihydrate as a green crystal.

1. customColor of the reaction liquid
2. temperatureSubsequently, the reaction mixture was cooled to 58° C.
3. temperatureAfter cooling the reaction mixture to 5° C.
4. filtrationthe crystal was collected by filtration
5. washwashed with 40 mL of acetone

ORD record

ord-695a3715d2b546eb94650678d277c3f0

Source dataset

uspto-grants-2015_08

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09108928B2