Methyl 4-bromobenzoate → 4-Bromobenzohydrazide

HRID 516477

Reaction equation

HRID 516477 reaction equation
C[O:2][C:3](=O)[C:4]1[CH:9]=[CH:8][C:7]([Br:10])=[CH:6][CH:5]=1.O.[NH2:13][NH2:14]>C(O)C>[Br:10][C:7]1[CH:8]=[CH:9][C:4]([C:3]([NH:13][NH2:14])=[O:2])=[CH:5][CH:6]=1

Participants

4

Reactant 2

HCID 12081Methyl 4-bromobenzoateHCID 24654Hydrazine hydrate (1:1)

Product 1

HCID 222194-BromobenzohydrazideYield 67%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

First, 3.0 g (13.9 mmol) of methyl-4-bromobenzoate was put in a 100-mL three-neck flask, 10 mL of ethanol was added thereto, and the mixture was stirred. Thereafter, 4.0 mL of hydrazine monohydrate was added thereto, and the mixture was heated and stirred at 78° C. for 5 hours. The obtained solid was washed with water and collected by suction filtration; thus, 2.0 g of a white solid of 4-bromobenzohydrazide that was an object was obtained in the yield of 67%.

Workup

  1. temperaturethe mixture was heated
  2. stirringstirred at 78° C. for 5 hours
  3. washThe obtained solid was washed with water
  4. filtrationcollected by suction filtration
  5. customwas obtained in the yield of 67%

Sources & evidence

ORD record
ord-b7a9aeaee135487680a28efcce79c560
Source dataset
uspto-grants-2015_08
Patent number
US09112170B2

Linked notes

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