Diethylamine → 3-Bromo-n,n-diethylpropanamide

HRID 520955

Reaction equation

HRID 520955 reaction equation
[Br:1][CH2:2][CH2:3][C:4](Cl)=[O:5].[CH2:7]([NH:9][CH2:10][CH3:11])[CH3:8]>C1COCC1>[Br:1][CH2:2][CH2:3][C:4]([N:9]([CH2:10][CH3:11])[CH2:7][CH3:8])=[O:5]

Participants

4

Reactant 2

HCID 8021DiethylamineHCID 84944Propanoyl chloride, 3-bromo-

Product 1

HCID 2261123-Bromo-n,n-diethylpropanamide

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
0 °C

Procedure

A mixture of 3-bromopropanoyl chloride (1.0 g, 5.8 mmol) and diethylamine (1.9 g, 26 mmol) in THF (20 ml) was stirred at 0° C. for 30 min, the resulting white solid was filtered and the filtrate was concentrated to give a crude oil which was used in the next reaction without further purification.

Workup

  1. filtrationthe resulting white solid was filtered
  2. concentrationthe filtrate was concentrated
  3. customto give a crude oil which
  4. customwas used in the next reaction without further purification

Sources & evidence

ORD record
ord-6bd54bd2fc00455abfe006191650235f
Source dataset
uspto-grants-2016_05
Patent number
US09328067B2

Linked notes

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