Potassium Carbonate → 3-((2-amino-4-chlorophenyl)thio)-N,N-diethylpropanamide

HRID 520956

Reaction equation

HRID 520956 reaction equation
[NH2:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[SH:9].Br[CH2:11][CH2:12][C:13]([N:15]([CH2:18][CH3:19])[CH2:16][CH3:17])=[O:14].C([O-])([O-])=O.[K+].[K+]>CN(C=O)C>[NH2:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[S:9][CH2:11][CH2:12][C:13]([N:15]([CH2:18][CH3:19])[CH2:16][CH3:17])=[O:14]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 120002-Amino-4-chlorobenzenethiolHCID 2261123-Bromo-n,n-diethylpropanamide

Product 1

HCID 866909943-((2-amino-4-chlorophenyl)thio)-N,N-diethylpropanamideYield 88%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Following General Procedure A, the title compound (1.0 g, 88%) was prepared from 2-amino-4-chlorobenzenethiol (660 mg, 4.13 mmol), crude 3-bromo-N,N-diethylpropanamide (860 mg, 6.60 mmol) and K2CO3 (2.9 g, 20.67 mmol) in DMF (20 ml).

Sources & evidence

ORD record
ord-f5bc7b32479543f899791f54faab608d
Source dataset
uspto-grants-2016_05
Patent number
US09328067B2

Linked notes

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